As a nonprofit, independent research institute, MTPPI conducts its studies in a scientifically rigorous manner using state-of-the-art methodologies. MTPPI ensures that project sponsorship does not influence the collection, analysis, and interpretation of the data or its subsequent dissemination. MTPPI publishes its findings in renowned peer-reviewed journals and its official research policy meets the highest standards advocated by the National Institutes of Health.
A Selection of Current Research Projects
Open-Source Causal Inference Toolkit
CERBOT (Comparative Effectiveness Research Based on Observational Data to Emulate a Target Trial) is a tool for better comparative effectiveness research using observational data. The tool is designed to be used by a team of researchers, patients and stakeholders. CERBOT guides users conduct their observational analyses by 1) articulating their research question in terms of a hypothetical randomized trial (the target trial) and 2) specifying how to emulate the target trial using observational data.
Did the ESRD Payment Bundle Teach Efficiency?
In January 2011, major payment reforms were implemented by the Centers for Medicare and Medicaid Services (CMS) for the treatment of patients with End-Stage Renal Disease (ESRD) on dialysis. These reforms focus on curtailing the rapid spending growth in the population of dialysis patients and include prospective bundled payments and pay-for-performance incentives in the effort to curb costs, while still incentivizing quality of care and improving the efficiency of the care delivered.
CI Software D&I Into Four Research Centers
Executing software implementations into large research enterprises can be a big undertaking. MTPPI researchers developing a framework of best practices, strategies, and solutions to mitigate g-methods implementation barriers. Using interview protocols based on the CFIR, researchers will capture in detail the role played by contextual factors when measuring competence. We’ll also measure fidelity (via QIF 14-steps), acceptability (via WEVAL and Kirkpatrick Model), and sustainability.
VA Type and Affect on Elderly HD Patient Outcomes
The optimal type of initial permanent access for hemodialysis among the elderly is controversial. Duration of central venous catheter dependence, patient comorbidities, and life expectancy are important considerations in whether to place an arteriovenous fistula or graft. MTPPI researchers are using an observational study design to compare clinical outcomes in elderly patients who initiated hemodialysis with a central venous catheter and subsequently had an arteriovenous fistula or graft placed.