Renal Failure Research


In terms of morbidity, mortality, and economic costs, End Stage Renal Disease (ESRD) is among the most serious chronic diseases in the United States. ESRD results from the permanent loss of kidney function and, without a regular course of dialysis or kidney transplantation, the disease is fatal. In 1991 Medicare insured approximately 93% of the 142,488 dialysis patients with kidney failure through the ESRD program established in 1973.

Current work includes:

  • Access to transplantation
  • Recombinant Human Erythropoietin
  • MTPPI recently announced an NIH grant to fund a study titled "Epoetin Therapy and Survival of Hemodialysis Patients". The abstract of that study is available here

    Institute researchers will also be giving a talk at the 2005 National Kidney Foundation meeting in Washington, DC entitled "Making Sense of Retrospective Database Studies- How Much Weight Do We Give to These Studies?" For further information regarding the meeting, click on: http://www.kidney.org/meetings/clinical/pdf/CM05_Physicians.pdf

    The Institute is also preparing comments on the rule proposed on 2/4/2005 by the Centers for Medicare and Medicaid Services regarding conditions for coverage: http://www.cms.hhs.gov/cop/3818.pdf. Our comments related to the proposed rule for monitoring claims for erythropoietin is also available here

    Recent and upcoming posters:

  • Factors affecting route of administration for Epoetin therapy among U.S. dialysis patients. ISPOR 10th Annual International Meeting, Marriott Wardman Park Hotel, Washington DC, May 15-18 2005
  • Epoetin therapy and survival: Evidence-based reviews, clinical practice guidelines, and regulatory decisions. 41st DIA Annual Meeting, Washington, DC June 26-30, 2005
  • Therapeutic risk management: A case study of recombinant human erythropoetin therapy among renal failure patients. 21st International Conference on Pharmacoepidemiology and Therapeutic Risk Management, Nashville, TN, August 21-24, 2005 (accepted for presentation).
  • Translating research into practice: Case study of erythroietin therapy for renal failure patients. American College of Epidemiology (ACE) Conference, New Orleans, September 17 - 20, 2005 (accepted for presentation)
  • Past Activities

    The following studies were conducted by MTPPI or have been submitted for publication. They examine important health services research and economic issues related to renal failure:

    • The role of patient weight in initial dosing of recombinant erythropoietin
    • Compliance with anti-graft rejection therapy following kidney transplantation
    • Epidemiology of psychiatric illness in the U.S. end-stage renal disease program
    • Drug use concomitant with cyclosporine immunosuppresive therapy for three years after renal transplantation
    • Access to kidney transplantation in California based on insurance status and sociodemographic and clinical characteristics.
    • Dose response of recombinant erythropoietin among hemodialysis patients
    • Conditions influencing renal patient survival

    Do you have an idea for a research topic? MTPPI is always looking for research topics that can help the community and industry better utilize new medical technologies. Let us know.

    Publications

    Some recent publications prepared by the Institute in this field are:

     

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